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TB Manual Chapter 7: Diagnosis of LTBI

TB Manual Chapter 7: Diagnosis of LTBI provides information on the classification and diagnosis of patients with latent tuberculosis infection (LTBI) via tuberculin skin testing (TST) or interferon gamma release assays (IGRA). Administration and interpretation of TST and IGRA are outlined here also. Certain factors identify persons at high risk for tuberculosis (TB) infection and/or for progression to TB disease such as being a contact of a smear-positive TB case, persons with HIV infection or other immunocompromising conditions, infants and children under age five, recent immigrants from countries with high incidence of TB, etc.

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