TB Manual Chapter 8: Treatment of LTBI discusses who to treat for latent tuberculosis infection (LTBI), including people in high-risk groups, susceptible contacts, and those with positive tuberculin skin test (TST) results. Treatment regimens and dosages are identified, including the importance of directly observed therapy (DOT) for those at high risk for TB, or those at risk of nonadherence or on an intermittent dosing regimen. This chapter provides side effects and adverse reactions to anti-TB medications that should garner additional attention. It also addresses the importance of monitoring patients for adherence to treatment, since effectiveness of the regimen decreases with non-adherence. Lastly, it includes completion of therapy as well as treatment for special situations, HIV infection, alcoholism, and pregnancy and breastfeeding.
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